Siglec-3/CD33, a sialic-acid-binding lectin, crucially mediates cell-cell interactions and immune cell quiescence. Preferring sialic acid on specific mucins, it forms homodimers, interacting with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. CD33 also engages C1QA through its C-terminus, activating CD33 inhibitory motifs. Siglec-3/CD33 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-3/CD33 protein, expressed by HEK293 , with C-6*His labeled tag.
Molekulargewicht:
30-45 kDa
Reinheit:
98
Formel:
12489(Gene_ID)Q63994-1 (D18-E240)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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