IL-18R beta/IL-1R7, Human (HEK293, His) Preis auf Anfrage

Produktübersicht

• Artikelname: IL-18R beta/IL-1R7, Human (HEK293, His) Preis auf Anfrage
• Artikelnummer: MCE-HY-P72573
• Hersteller Artikelnummer: HY-P72573
• Alternativnummer: MCE-HY-P72573-10UG,MCE-HY-P72573-50UG
• Hersteller: MedchemExpress
• Kategorie: Proteine/Peptide
• Alternative Synonym: IL-18R beta/IL-1R7 Protein, Human (HEK293, His),Human,HEK293

Produktbeschreibung

IL-18 is a pleiotropic proinflammatory cytokine that is involved in induction of inflammatory mediators, regulation of the cytotoxic activity of NK cells and T cells, and differentiation and activation of both Th1 and Th2 cells. IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Ralpha and IL-18R beta. IL-18 forms a signalling complex with the IL-18 receptor alpha (Ralpha) and beta (Rbeta) chains at the plasma membrane, which induces multiple inflammatory cytokines[2]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kbeta- inducing kinase, with subsequent activation of NF- kbeta[3].IL-18R betaknockdown inhibits IL-18 driven tumor cell metastasis in C57/BL6 mice[4]. IL-18R beta/IL-1R7 Protein, Human (HEK293, His) is a recombinant protein with a His label that is produced by HEK293 cells.

Produkteigenschaften

• Molekulargewicht: Approximately 56 kDa,based on SDS-PAGE under reducing conditions.
• Formel: 8807(Gene_ID)O95256-1 (F20-R356)(Accession)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Recombinant Proteins