DKK-1 protein antagonizes canonical Wnt signaling by inhibiting LRP5/6-Wnt interaction and forming a ternary complex with KREMEN, thereby promoting LRP5/6 internalization. In addition to its Wnt-dependent role, DKK1 has Wnt-independent anti-apoptotic activity by inhibiting the pro-apoptotic function of KREMEN1. DKK-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DKK1 protein, expressed by HEK293 , with C-His labeled tag.
Molekulargewicht:
Approximately 38.29 kDa
Reinheit:
98
Formel:
13380(Gene_ID)O54908 (T32-H272)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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