Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation[1]. NGF-NGFR cascade activates NF-kappaB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells[3]. NGFR Protein, Human (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 250 amino acids (M1-N250) and is produced in HEK293 cells.
Molekulargewicht:
Approximately 70-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formel:
4804(Gene_ID)P08138-1 (K29-N250)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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