Noggin is an antagonist of bone morphogenetic proteins (BMPs) and a member of the TGF-beta superfamily, existing as a homodimer. Noggin binds to BMP-2/-4/-7 and inhibits their binding to BMPR-I/II receptors, thereby synergistically inducing bone differentiation in HMSCs, maintaining pluripotency in hESCs, inhibiting angiogenesis in HUVECs, and promoting myelination in oligodendrocytes, exerting neural activity[1][2][3][4]. Noggin Protein, Human (HEK293, Fc) is a recombinant human Noggin protein expressed in HEK293 cells with C-His tag.
Molekulargewicht:
Approximately 30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
