RANKL (TNFSF11), a type II transmembrane protein, is a receptor activator of NF-kappaB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Mouse (HEK293, Fc) is a recombinant mouse RANKL (R72-D316) with N-terminal hFc tag, which is produced in HEK293[1][2].
Molekulargewicht:
Approximately 50-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
