Sonic Hedgehog (SHH) Protein is a secretory glycoprotein of the Hedgehog family that can self-cleave to form N-SHH. SHH Protein activates Smo by binding to Frizzled and LRP6, inhibits GSK-3beta to stabilize beta-catenin, and activates FOXM1. SHH Protein also promotes NO release and shortens myocardial APD by phosphorylating eNOS through PI3K/Akt. SHH Protein can promote the maturation of sweat gland cells in three-dimensional culture and play a cardioprotective role in the pig ischemia-reperfusion model[1][2]. SHH Protein, Human (C24IVI) is a recombinant human SHH protein expressed in E. coli with C24IVI-mutation and tag-free.
Molekulargewicht:
Approximately 20 kDa, based on SDS-PAGE under reducing conditions.
Reinheit:
95.00
Formel:
6469(Gene_ID)Q15465 (G25-G197)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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