RANKL (TNFSF11), a type II transmembrane protein, is receptor activator of NF-kappaB (RANK) ligand. RANKL is an activator of RANK. When binding to RANK, it induces the differentiation of monocyte/macrophage-lineage cells into osteoclasts and leads to osteoclast precursor maturation. RANKL is critical for osteoclasts maturation, bone modeling, and bone remodeling, as well as the development of lymph nodes (LNs). RANKL/TNFSF11 Protein, Human is a recombinant human RANKL (I140-D317) without any tag, which is produced in E.coli[1][2].
Molekulargewicht:
Approximately 20 kDa, based on SDS-PAGE under reducing conditions.
Reinheit:
98
Formel:
8600(Gene_ID)O14788-1 (I140-D317)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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