KIR2DL1, found on NK cells, serves as a receptor for specific HLA-C alleles, inhibiting NK cell activity to prevent cell lysis. This regulatory function involves interactions with ARRB2 and, additionally, engages PTPN6 and PTPN11. The interactions enhancement by ARRB2 underscores KIR2DL1s role in complex signaling networks that modulate NK cell function. KIR2DL1 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL1 protein, expressed by HEK293 , with C-His labeled tag.
