Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFbeta family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA)[1]. Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2[2], or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation[3].
Molekulargewicht:
Approximately 50-55 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Reinheit:
89.10
Formel:
653(Gene_ID)NP_066551.1 (Q324-H454)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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