Fas receptor is a cell surface death receptor, can bind to Fas ligand to form death-inducing signaling complexes, such as Fas associated death domain proteins (FADD)[1][2]. Fas receptor participates in the caspase cascade and regulate the activation of JNK and p38-K downstream. It is also involved in the signaling cascade of ERK/JNK MAPKs, activating MAPK3/ERK1, MAPK8/JNK and NF-kappaB, which has been implicated in the pathogenesis of various malignant tumors and immune system diseases[3][4]. Macaca mulatta Fas receptor contain a death domain (228-312 a.a.) that plays a key role in regulating programmed death. Fas/CD95 Protein, Cynomolgus (HEK293, Fc) is produced in HEK293 cells with C-terminal hFc-tag.
Molekulargewicht:
Approximately 47-57 kDa,based on SDS-PAGE under reducing conditions.
Formel:
/(Gene_ID)F6V1W6 (Q26-D173)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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