IL-18R alpha (interleukin-18 receptor alpha) is an interleukin receptor of the immunoglobulin superfamily. IL-18 forms a signalling complex with the IL-18 receptor alpha (Ralpha) and beta (Rbeta) chains at the plasma membrane, which induces multiple inflammatory cytokines[1]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kbeta- inducing kinase, with subsequent activation of nuclear factor kbeta[2]. IL-18R alpha inhibits the production of IFN-gamma stimulated with the combination of rhIL-2 and rhIL-18[3]. IL-18R alpha Protein, Cynomolgus (HEK293, His) is a recombinant protein with a His label that consists of 315 amino acids (M1-K315) and is produced by HEK293 cells.
Molekulargewicht:
Approximately 55 kDa due to the glycosylation
Reinheit:
97.00
Formel:
/(Gene_ID)F7H8F9 (C22-K315)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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