IL-18 is a pleiotropic proinflammatory cytokine that is involved in induction of inflammatory mediators, regulation of the cytotoxic activity of NK cells and T cells, and differentiation and activation of both Th1 and Th2 cells. IL-18 signals through its specific cell surface receptor IL-18R, which comprises two subunits: IL-18Ralpha and IL-18R beta. IL-18 forms a signalling complex with the IL-18 receptor alpha (Ralpha) and beta (Rbeta) chains at the plasma membrane, which induces multiple inflammatory cytokines[2]. IL-18R complex recruits the IL-1R- activating kinase and TNF- associated factor 6, which phosphorylates nuclear factor kbeta- inducing kinase, with subsequent activation of NF- kbeta[3].IL-18R betaknockdown inhibits IL-18 driven tumor cell metastasis in C57/BL6 mice[4]. IL-18RAP Protein, Rhesus Macaque (HEK293, His) is a recombinant protein with a His label that consists of 357 amino acids (M1-R356) and is produced by HEK293 cells.
Molekulargewicht:
Approximately 52-75 kDa, based on SDS-PAGE under reducing conditions.
