CRTAM/CD355 protein regulates T-cell subsets by mediating cell-cell adhesion. It interacts with CADM1 to enhance NK cell cytotoxicity, IFNG secretion by CD8+ T-cells, and NK cell-mediated tumor rejection. CRTAM regulates CD8+ T-cell proliferation but not cytotoxicity. It also promotes CD4+ T-cell polarization and regulates TCR-mediated proliferation and cytokine production. CRTAM contributes to the retention of activated CD8+ T-cells in lymph nodes and intestinal retention of intraepithelial T-cells. It may exist as a monomer or homodimer and interacts with SCRIB to promote polarization in CD4+ T-cells. CRTAM/CD355 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived CRTAM/CD355 protein, expressed by HEK293 , with C-hFc labeled tag.
Molekulargewicht:
Approximately 70-80 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
