Growth differentiation factor 15 (GDF-15) is a polypeptide hormone belonging to the transforming growth factor beta (TGF-beta) superfamily. GDF-15 is also known as non-steroidal anti-inflammatory drug activating Gene-1 (NAG-1), placental transforming growth factor-beta (PTGFB), prostate-derived factor (PDF), and placental bone morphogenetic protein (PLAB). GDF-15 binds to glial cell-derived neurotrophic factor (GDNF) family receptor alpha-like protein (GFRAL) and is involved in aging, cancer, and metabolic processes. GFRAL-GDF15 does not affect SMAD activity and activates intracellular signals including RET, AKT, ERK1/2, and phospholipase C (PLCgamma)[1]. GDF-15 Protein, Cynomolgus (HEK293, Fc) has 112 amino acids expressed by HEK293 cells with N-terminal hFc tag.
Molekulargewicht:
Approximately 40-50 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formel:
102117226(Gene_ID)G7PWZ3 (A197-V308)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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