Human IL-23 alpha & Mouse IL-12 beta Heterodimer (HEK293, His-Avi) Preis auf Anfrage
Artikelnummer:
MCE-HY-P77712
Hersteller Artikelnummer:
HY-P77712
Alternativnummer:
MCE-HY-P77712-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Proteine/Peptide
Alternative Synonym:
Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi),Human,Mouse,HEK293
IL-23 alpha and IL-12 beta are the IL-23p19 and IL-12p40 subunits, respectively, composing IL-23 via heterodimerization manner. IL-23 binds to a heterodimeric receptor composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, acts on memory CD4(+) T cells preferentially[1]. IL-23 also involves in activation of several pathways including p38 MAPK or NF-kappaB and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A[2]. Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein is produced in HEK293 cells, with a C-Terminal Avi and His-tag.
Molekulargewicht:
Approximately 22 kDa (Human IL-23 alpha) & 45-60 kDa (Mouse IL-12 beta),based on SDS-PAGE under reducing conditions,due to the glycosylation.
