AITRL/TNFSF18 Trimer, Human (Biotinylated, HEK293, His-Flag)

Produktübersicht

• Artikelname: AITRL/TNFSF18 Trimer, Human (Biotinylated, HEK293, His-Flag)
• Artikelnummer: MCE-HY-P78133
• Hersteller Artikelnummer: HY-P78133
• Alternativnummer: MCE-HY-P78133-50UG,MCE-HY-P78133-20UG
• Hersteller: MedchemExpress
• Kategorie: Proteine/Peptide
• Alternative Synonym: AITRL/TNFSF18 Trimer Protein, Human (Biotinylated, HEK293, His-Flag),Human,HEK293

Produktbeschreibung

AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Human (Biotinylated, HEK293, His-Flag) is a recombinant biotinylated human AITRL (Q72-S199) with N-terminal His and Flag tag, which is expressed in HEK293.

Produkteigenschaften

• Molekulargewicht: Approximately 50-70 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
• Reinheit: 95
• Formel: 8995(Gene_ID)Q9UNG2 (Q50-S177)(Accession)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Recombinant Proteins