AITRL, a type II transmembrane protein, is a ligand for glucocorticoid-induced TNFR-related protein (GITR). When AITRL binds to GITR, GITR can produce costimulatory signals that regulate T-cell proliferation and effector functions. GITR/AITRL interaction plays a role in the pathogenesis of tumor, inflammation, as well as autoimmune diseases[1]. Besides, AITRL plays a role in endothelial cells (EC)-activation and increases STAT-1 phosphorylation and the expression of adhesion molecules (VCAM-1, ICAM-1)[2]. AITRL/TNFSF18 Protein, Mouse (HEK293, Fc) is a recombinant mouse AITRL (T47-S173) with N-terminal hFc tag, which is expressed in HEK293.
Molekulargewicht:
Approximately 50-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
Reinheit:
95.00
Formel:
240873(Gene_ID)Q7TS55 (T47-S173)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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