IFNAR1, one of the subunit of IFN-alpha/beta receptor, is a type I IFN receptor. IFNAR1 forms the heterodimeric receptor with IFNAR2. IFNAR1 mediates IFN-induced STAT signaling by interacting with tyrosine kinase 2 (Tyk2)[1][2]. Upon activation by these IFNs, IFNAR1 and IFNAR2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFNAR1 Protein, Mouse (HEK293, Fc) is a recombinant mouse IFNAR1 (E27-T429) with C-terminal His and Avi tags, which is produced in HEK293 cells.
Molekulargewicht:
Approximately 60-70 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Formel:
15975(Gene_ID)P33896 (E27-T429)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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