Norrin protein activates canonical Wnt signaling by binding to FZD4 and LRP5, promotes retinal vascularization and stabilizes beta-catenin (CTNNB1). It cooperates with TSPAN12 to independently activate FZD4, suggesting a Wnt-independent mechanism. Norrin Protein, Human is the recombinant human-derived Norrin protein, expressed by E. coli , with tag free.
Molekulargewicht:
Approximately 13 kDa
Reinheit:
96
Formel:
4693(Gene_ID)Q00604 (K25-S133)(Accession)
Anwendungsbeschreibung:
MCE Product type: Recombinant Proteins
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