Perenostobart, CAS [[2643331-31-9]]

Produktübersicht

• Artikelname: Perenostobart, CAS [[2643331-31-9]]
• Artikelnummer: MCE-HY-P990068
• Hersteller Artikelnummer: HY-P990068
• Alternativnummer: MCE-HY-P990068-10MG,MCE-HY-P990068-1MG,MCE-HY-P990068-5MG
• Hersteller: MedchemExpress
• Kategorie: Antikörper
• Alternative Synonym: SRF617

Produktbeschreibung

Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC50 values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4+ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer[1].

Produkteigenschaften

• Molekulargewicht: (145.5 kDa)
• Reinheit: 97.00
• CAS Nummer: [2643331-31-9]
• Target-Kategorie: NTPDase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Inhibitory Antibodies