Givastomig, CAS [[2762499-30-7]]

Produktübersicht

• Artikelname: Givastomig, CAS [[2762499-30-7]]
• Artikelnummer: MCE-HY-P990742
• Hersteller Artikelnummer: HY-P990742
• Alternativnummer: MCE-HY-P990742-10MG,MCE-HY-P990742-1MG,MCE-HY-P990742-5MG
• Hersteller: MedchemExpress
• Kategorie: Antikörper
• Alternative Synonym: TJ-CD4B, ABL111, TJ033721

Produktbeschreibung

Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma[1].

Produkteigenschaften

• Molekulargewicht: (201.929 kDa)
• Reinheit: 98.556
• CAS Nummer: [2762499-30-7]
• Target-Kategorie: Claudin,TNF Receptor

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Inhibitory Antibodies