GBR-401 is a humanized anti-CD19 monoclonal antibody with high affinity for FcgammaRIIIa. GBR-401 exerts a potent in vitro and in vivo cytotoxic activity against various B-cell malignancies. GBR-401 induces cell death by antibody dependent cellular cytotoxicity (ADCC) and direct killing effect. GBR-401 demonstrates potent activity of depleting malignant B cells and prolongs mice survival in multiple xenograft severe combined immunodeficiency (SCID) mice models[1].
CAS Nummer:
[1931954-95-8]
Target-Kategorie:
CD19
Anwendungsbeschreibung:
Inhibitory Antibodies
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