Anti-Mouse CXCR4 Antibody (Cx4Mab-1) Preis auf Anfrage
Artikelnummer:
MCE-HY-P991744
Hersteller Artikelnummer:
HY-P991744
Alternativnummer:
MCE-HY-P991744-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Antikörper
Anti-Mouse CXCR4 Antibody is a monoclonal antibody that specifically recognizes murine CXCR4 (C-X-C chemokine receptor 4), also known as fusin or CD184. CXCR4 is a seven-transmembrane G protein-coupled receptor whose principal endogenous ligand is CXCL12 (stromal cell-derived factor-1alpha, SDF-1alpha) and is widely expressed in hematopoietic cells, endothelial cells, neurons, as well as embryonic and adult stem cells. The CXCR4-CXCL12 signaling axis activates multiple downstream pathways, including ERK1/2, Ras, p38 MAPK, PLC/MAPK, and SAPK/JNK, thereby regulating cell survival, proliferation, migration, and stemness maintenance. Aberrant overexpression of CXCR4 is closely associated with poor prognosis and metastasis in various cancers, with CXCR4-positive tumor cells preferentially home to CXCL12-rich tissues such as the liver, bone marrow, lung, and lymph nodes. Accordingly, CXCR4 and its CXCL12-related antagonists emerge as attractive targets for experimental anticancer therapy. Anti-Mouse CXCR4 Antibody is generated using a cell-based immunization and screening strategy and exhibits high affinity for both endogenous and exogenous murine CXCR4. Anti-Mouse CXCR4 Antibody can be used for thestudy of chronic lymphocytic leukemia and multiple myeloma[1].
Target-Kategorie:
CXCR
Anwendungsbeschreibung:
MCE Product type: Screening Libraries
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