KY1070 is a fully human anti-BMP6 antibody with a Kd of 0.00014 µM against the human BMP6. It exhibits high specificity for BMP6, showing no cross-reactivity with other members of the BMP family, and effectively inhibits BMP6-induced BMP receptor heterodimerization and hepcidin expression. KY1070 modulates Ferroportin expression on erythroid progenitor cells and accelerates erythropoiesis. In rodent anemia models, KY1070 reduces the required dose of erythropoietin (EPO) when used in combination with EPO and enhances the responsiveness of mice with chronic kidney disease (CKD)-associated anemia to EPO treatment. KY1070 is applicable for research on anemia of chronic disease [1] [2].
Target-Kategorie:
Ferroportin,Hepcidin,TGF-beta Receptor
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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