SK48-E26 is a human interleukin-1beta (IL-1beta) inhibitor, with a IC50 of 400 pM against human IL-1beta, a IC50 of 185 pM against cynomolgus monkey IL-1beta, and a Ka value ranging from 0.048 nM to 3 nM for human IL-1beta. SK48-E26 binds to the conformational epitope of human IL-1beta spanning amino acid residues 95-101, and blocks the biological activity of IL-1beta. SK48-E26 can be used in research related to IL-1beta-mediated inflammatory diseases and osteoarthritis[1][2].
Target-Kategorie:
Interleukin Related
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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