Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers[1].
Molekulargewicht:
(146.1 kDa)
Reinheit:
99.54
CAS Nummer:
[1781223-80-0]
Target-Kategorie:
Apoptosis,c-Met/HGFR
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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