KY-1044, CAS [[2489390-15-8]]

Produktübersicht

• Artikelname: KY-1044, CAS [[2489390-15-8]]
• Artikelnummer: MCE-HY-P99431
• Hersteller Artikelnummer: HY-P99431
• Alternativnummer: MCE-HY-P99431-10MG,MCE-HY-P99431-5MG,MCE-HY-P99431-1MG
• Hersteller: MedchemExpress
• Kategorie: Antikörper
• Alternative Synonym: Alomfilimab, SAR 445256

Produktbeschreibung

KY-1044 (Alomfilimab, SAR 445256) is a fully human IgG1 antibody targeting inducible costimulatory receptor (ICOS). KY-1044 depletes ICOShigh cells via antibody-dependent cellular cytotoxicity (ADCC) through the engagement of FcgRIIIa. KY-1044 act as a costimulatory molecule on cells expressing lower ICOS levels, such as CD8+ TEff cells (through FcgR-dependent clustering). KY-1044 exploit the differential expression of ICOS on T-cell subtypes to improve the intratumoral immune contexture and restore an antitumor immune response[1].

Produkteigenschaften

• Molekulargewicht: (146.5 kDa)
• Reinheit: 99.51
• CAS Nummer: [2489390-15-8]
• Target-Kategorie: CD28

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Inhibitory Antibodies