Cinrebafusp alfa (PRS 343) is a high affinity CD137/HER2 bispecfic anticalin-based drug. Cinrebafusp alfa binds to recombinant human HER2 (Kd=0.3 nM) and human monomeric CD137 (4-1BB, Kd=5 nM). Cinrebafusp alfa facilitates T-cell costimulation by tumor-localized, HER2-dependent 4-1BB clustering and activation, further enhancing T-cell receptor-mediated activity and leading to tumor destruction. Cinrebafusp alfa has the potential for HER2+ solid tumors research[1][2].
Molekulargewicht:
(187.87 kDa)
Reinheit:
98.53
CAS Nummer:
[2218515-90-1]
Target-Kategorie:
EGFR,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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