Modakafusp alfa (TAK-573) is a humanized, anti-CD38 IgG4 monoclonal antibody fused to 2 attenuated IFNalpha2b molecules, which delivers interferon-alpha to CD38-expressing cells. Modakafusp alfa has direct anti-proliferative activity on multiple myeloma (MM) cancer cells in vitro and induces robust and durable antitumor responses in MM xenograft tumor models. Modakafusp alfa in combination with anti-PD-1 antibodies induces immunomodulation and antitumor responses with good tolerance in mice[1][2][3][4].
Molekulargewicht:
(183.48 kDa)
Reinheit:
96.22
CAS Nummer:
[2254522-19-3]
Target-Kategorie:
CD38
Anwendungsbeschreibung:
MCE Product type: Inhibitory Antibodies
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