BOC-(1R,3S)-3-aminocyclopentane carboxylic acid is a conformationally constrained peptide building block and a key component of SARS-CoV-2 main protease (Mpro) inhibitors. When incorporated into macrocyclic peptides, BOC-(1R,3S)-3-aminocyclopentane carboxylic acid not only helps generate high-affinity Mpro inhibitors by preorganizing the secondary structure of peptides, but also exerts sequence-dependent functional inhibition on the hydrolytic activity of Mpro. BOC-(1R,3S)-3-aminocyclopentane carboxylic acid significantly enhances the ability of macrocyclic peptides to resist peptidase-mediated degradation in human serum, and is widely used in COVID-19-related research[1].
Molekulargewicht:
229.28
Reinheit:
98
CAS Nummer:
[161660-94-2]
Formel:
C11H19NO4
Target-Kategorie:
Drug Intermediate,SARS-CoV
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten