MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinsons disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
Molekulargewicht:
297.14
Reinheit:
99.94
CAS Nummer:
[36913-39-0]
Formel:
C12H12IN
Target-Kategorie:
Mitochondrial Metabolism
Anwendungsbeschreibung:
MCE Product type: Reference compound
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