Inosine-5-diphosphate-15N4 dilithium (IDP-15N4 dilithium) is 15N labeled Inosine-5-diphosphate dilithium. Inosine-5-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (KD: 5.0 µM). Inosine-5-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of gamma-irradiation. Inosine-5-diphosphate can be used for cancers like Burkitts lymphoma and cardiovascular diseases research[1][2][3][4].
Molekulargewicht:
444.03
Formel:
C10H12Li2 15N4O11P2
Target-Kategorie:
Apoptosis,c-Myc,Isotope-Labeled Compounds
Anwendungsbeschreibung:
MCE Product type: Isotope-Labeled Compounds
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