AP-18, a potent and selective TRPA1 inhibitor, blocks activation of TRPA1 by 50 µM Cinnamaldehyde with an IC50 of 3.1 µM and 4.5 µM for human and mouse TRPA1, respectively. AP-18 reverses complete Freunds adjuvant (CFA)-induced mechanical hyperalgesia in mice. AP-18 attenuated 30 µM AITC-induced Yo-Pro uptake in a concentration-dependent manner, with an IC50 of 10.3 µM[1][2][3].
Molekulargewicht:
209.67
Reinheit:
99.61
CAS Nummer:
[55224-94-7]
Formel:
C11H12ClNO
Target-Kategorie:
TRP Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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