2-Acetamidophenol-d3 (Orthocetamol-d3) is the deuterium labeled 2-Acetamidophenol (HY-W015600). 2-Acetamidophenol (Orthocetamol) is a regulator that targets ferroptosis and glutathione metabolic pathways, is the ortho-regioisomer of Paracetamol (HY-66005). 2-Acetamidophenol has anti-atherosclerotic activity, and inhibiting total cholesterol (TC) and triglyceride (TG) in a zebrafish hyperlipidemia model with IC50s for 30 µM and 40 µM, respectively. 2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation[1][2].
Molekulargewicht:
154.18
Reinheit:
99.48
CAS Nummer:
[122258-87-1]
Formel:
C8H6D3NO2
Target-Kategorie:
Ferroptosis,Glutathione Peroxidase,Isotope-Labeled Compounds,LDLR,Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Isotope-Labeled Compounds
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