Hydrocinchonine (Dihydrocinchonine) is a multidrug resistance (MDR)-reversal agent. Hydrocinchonine directly inhibits the function and expression of P-gp, which is the mechanism by which it reverses MDR. Hydrocinchonine exerts synergistic apoptotic effect with Paclitaxel (HY-B0015) in MES-SA/DX5 cells. Hydrocinchonine can be used for the study of gynecological malignant tumors (such as uterine sarcoma) with drug resistance caused by excessive expression of P-gp[1].
Molekulargewicht:
296.41
Reinheit:
98.33
CAS Nummer:
[485-65-4]
Formel:
C19H24N2O
Target-Kategorie:
Apoptosis,P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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