Momelotinib (dihydrochloride) is a JAK1/JAK2 inhibitor that also antagonizes ACVR1, leading to downregulation of Hepcidin expression and increased availability of iron for erythropoiesis. Momelotinib (dihydrochloride) can reduce transfusion burden and spleen enlargement caused by myelofibrosis, showing potential value in research and application within the field of myelofibrosis[1].
Molekulargewicht:
487.38
CAS Nummer:
[1380317-28-1]
Formel:
C23H24Cl2N6O2
Target-Kategorie:
JAK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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