1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 µM, and its inhibition rate is more than 90% at a concentration of 20 µM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].
Molekulargewicht:
196.21
Reinheit:
99.70
CAS Nummer:
[20127-63-3]
Formel:
C12H8N2O
Target-Kategorie:
Akt,Influenza Virus
Anwendungsbeschreibung:
MCE Product type: Natural Products
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