MASTL/Aurora A-IN-1, CAS [[321945-24-8]] Preis auf Anfrage

Produktübersicht

• Artikelname: MASTL/Aurora A-IN-1, CAS [[321945-24-8]] Preis auf Anfrage
• Artikelnummer: MCE-HY-W231513
• Hersteller Artikelnummer: HY-W231513
• Alternativnummer: MCE-HY-W231513-25MG,MCE-HY-W231513-100MG,MCE-HY-W231513-5MG,MCE-HY-W231513-50MG,MCE-HY-W231513-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 µM and 0.16 µM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 µM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis[1].

Produkteigenschaften

• Molekulargewicht: 310.41
• Reinheit: 99.47
• CAS Nummer: [321945-24-8]
• Formel: C18H18N2OS
• Target-Kategorie: Aurora Kinase,MASTL,Ser/Thr Protease

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound