SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (Kd = 0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma[1].
Molekulargewicht:
263.73
CAS Nummer:
[958712-85-1]
Formel:
C13H14ClN3O
Target-Kategorie:
MDM-2/p53
Anwendungsbeschreibung:
MCE Product type: Reference compound
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