DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD+/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-kappaB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-alpha, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases[1][2][3].
Molekulargewicht:
325.79
CAS Nummer:
[84050-22-6]
Formel:
C14H20ClN5O2
Target-Kategorie:
PARP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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