Desmethylastemizole, CAS [[73736-50-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: Desmethylastemizole, CAS [[73736-50-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-W516880
• Hersteller Artikelnummer: HY-W516880
• Alternativnummer: MCE-HY-W516880-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: O-Demethylastemizole

Produktbeschreibung

Desmethylastemizole (O-Demethylastemizole) , a metabolite of Astemizole (HY-12532), is a beta-hematin (betaH) inhibitor. Desmethylastemizole has an antiplasmodium activity against P. falciparum with IC50 of 0.12, 0.11 and 0.06 µM for Pf3D7, PfDd2, and PfItG strains, respectively. Desmethylastemizole is also a Histamine H1 receptor antagonist. Desmethylastemizole significantly blocks hERG K+ channels and also inhibits histone-lysine N-methyltransferase EZH2 activity. Desmethylastemizole can be used for long QT syndrome and malaria research[1][2][3].

Produkteigenschaften

• Molekulargewicht: 444.54
• Reinheit: 98.26
• CAS Nummer: [73736-50-2]
• Formel: C27H29FN4O
• Target-Kategorie: Drug Metabolite,Histamine Receptor,Parasite,Potassium Channel

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound