Desmethylastemizole (O-Demethylastemizole) , a metabolite of Astemizole (HY-12532), is a beta-hematin (betaH) inhibitor. Desmethylastemizole has an antiplasmodium activity against P. falciparum with IC50 of 0.12, 0.11 and 0.06 µM for Pf3D7, PfDd2, and PfItG strains, respectively. Desmethylastemizole is also a Histamine H1 receptor antagonist. Desmethylastemizole significantly blocks hERG K+ channels and also inhibits histone-lysine N-methyltransferase EZH2 activity. Desmethylastemizole can be used for long QT syndrome and malaria research[1][2][3].
Molekulargewicht:
444.54
Reinheit:
98.26
CAS Nummer:
[73736-50-2]
Formel:
C27H29FN4O
Target-Kategorie:
Drug Metabolite,Histamine Receptor,Parasite,Potassium Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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