Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).
Molekulargewicht:
589.38
Reinheit:
98
CAS Nummer:
[727721-37-1]
Formel:
C22H17Cl2N3Pt
Target-Kategorie:
DNA/RNA Synthesis,G-quadruplex,Mitosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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