ADX68692 is an orally active negative allosteric modulators of follicle-stimulating hormone receptor with a log IC50 of -5.71. ADX68692 can inhibit hCG-induced cAMP production and s ß-arrestin 2 recruitment in HEK293 cells. ADX68692 exhibits a partial effect in both mLTC-1 and primary rat Leydig cells. ADX68692 inhibits FSHR-promoted cAMP, progesterone and estradiol production. ADX68692 can reduce the number of oocytes recovered from the ampullae[1][2].
Molekulargewicht:
401.46
CAS Nummer:
[1067191-08-5]
Formel:
C24H23N3O3
Target-Kategorie:
Estrogen Receptor/ERR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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