DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 µM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD)[1][2].
Molekulargewicht:
480.94
CAS Nummer:
[1346599-75-4]
Formel:
C26H25ClN2O5
Target-Kategorie:
P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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