Tambiciclib (dimaleate), CAS [[2559759-04-3]] Preis auf Anfrage

Produktübersicht

• Artikelname: Tambiciclib (dimaleate), CAS [[2559759-04-3]] Preis auf Anfrage
• Artikelnummer: MCE-HY-X0009A
• Hersteller Artikelnummer: HY-X0009A
• Alternativnummer: MCE-HY-X0009A-25MG,MCE-HY-X0009A-5MG,MCE-HY-X0009A-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: GFH009 (dimaleate), JSH-009 (dimaleate), SLS009 (dimaleate)

Produktbeschreibung

Tambiciclib (GFH009, JSH-009) dimaleate is an orally active, highly potent and selective CDK9 inhibitor (IC50 = 1 nM), demonstrating >200-fold selectivity over other CDKs, >100-fold selectivity over DYRK1A/B, and excellent selectivity over 468 kinases/mutants. Tambiciclib dimaleate demonstrates potent in vitro and in vivo antileukemic efficacy in acute myeloid leukemia (AML) mouse models by inhibiting RNA Pol II phosphorylation, downregulating MCL1 and MYC, and inducing apoptosis. Tambiciclib dimaleate can be used for AML research[1].

Produkteigenschaften

• Molekulargewicht: 751.25
• Reinheit: 99.99
• CAS Nummer: [2559759-04-3]
• Formel: C33H43ClN6O10S
• Target-Kategorie: Apoptosis,Bcl-2 Family,Caspase,CDK,c-Myc,DNA/RNA Synthesis,DYRK,PARP

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound