Pimelic acid is a seven-carbon alpha,omega-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism[1][2][3].
Molekulargewicht:
160.17
Reinheit:
98
CAS Nummer:
[111-16-0]
Formel:
C7H12O4
Target-Kategorie:
Endogenous Metabolite
Anwendungsbeschreibung:
MCE Product type: Natural Products
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