Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody, Clone: [CDH16/1532R], Rabbit, Monoclonal

Produktübersicht

• Artikelname: Recombinant Ksp-Cadherin (Kidney-Specific Cadherin) / CDH16 Antibody, Clone: [CDH16/1532R], Rabbit, Monoclonal
• Artikelnummer: NBT-1014-RBM2-P1ABX
• Hersteller Artikelnummer: 1014-RBM2-P1ABX
• Alternativnummer: NBT-1014-RBM2-P1ABX-100
• Hersteller: NeoBiotechnologies
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: FC, IHC, WB
• Spezies Reaktivität: Guinea pig, Hamster, Human, Mouse, Rabbit, Rat
• Immunogen: Recombinant human full-length CDH16 protein
• Alternative Synonym: Cadherin-16 (CDH16), Kidney-specific cadherin, Ksp-cadherin antibody

Produktbeschreibung

This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport. It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [CDH16/1532R]
• Molekulargewicht: 130kDa
• NCBI: 1014
• UniProt: O75309
• Formulierung: 200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Antibody Type: Recombinant Monoclonal Antibody

Anwendungsbeschreibung

• Anwendungsbeschreibung: Western Blot (1-2ug/ml), Flow Cytometry (1-2ug/million cells), ,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA buffer, pH 9.0, for 45 m

Bilder

Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Formalin-fixed, paraffin-embedded Rat Kidney stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Formalin-fixed, paraffin-embedded Mouse Kidney stained with KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

SDS-PAGE Analysis of Purified KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Western Blot Analysis of human Kidney lysate using KSP-Cadherin Rabbit Recombinant Monoclonal Antibody (CDH16/1532R)

Flow Cytometric Analysis of Human HEK293 cells using KSP-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/1532R) followed by Goat anti-rabbit IgG-CF488 (Blue), Isotype Control (Red).

Western Blot Analysis of Human Kidney, Mouse Kidney, Rat Kidney, Hamster Kidney, Guinea pig Kidney and Rabbit Kidney tissue lysates using Ksp-Cadherin Recombinant Rabbit Monoclonal Antibody (CDH16/1532R).