Clusterin, also known as apolipoprotein J (ApoJ), complement lysis inhibitor (CLI), gp80, glycoprotein III, sulfated glycoprotein 2 (SGP2), SP40-40, testosterone-repressed prostate message 2 (TRPM2), and T64, is a secretory, heterodimeric glycoprotein of approximately 80 kD composed of two disulfide-linked subunits, alpha (residues 228,Ai449) and beta (residues 23,Ai227). It is synthesized as a 449-amino acid polypeptide and post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Clusterin interacts with a broad range of molecules and plays a role in diverse biological processes, including immune regulation, lipid transport, sperm maturation, complement cascade regulation, membrane recycling, cell adhesion, morphological transformation, tissue remodeling, and cell-cell interactions. It also influences -amyloid structure and neuritic toxicity in vivo, suggesting a potential role in Alzheimer,Aos disease pathogenesis. Notably, Clusterin overexpression is more common in the late stages of mammary tumor progression.
200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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