Desmoglein-1 (DSG1) Antibody, IgG2a, Clone: [MSVA-544M], Mouse, Monoclonal

Produktübersicht

• Artikelname: Desmoglein-1 (DSG1) Antibody, IgG2a, Clone: [MSVA-544M], Mouse, Monoclonal
• Artikelnummer: NBT-1828-MSM9-P1
• Hersteller Artikelnummer: 1828-MSM9-P1
• Alternativnummer: NBT-1828-MSM9-P1-100
• Hersteller: NeoBiotechnologies
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: IHC
• Spezies Reaktivität: Human
• Immunogen: Bovine desmoglein (desmosomal glyco protein I) from nasal epidermis.
• Alternative Synonym: Cadherin family member 4, CDHF4, Desmoglein-1, Desmosomal glycoprotein 1, DG1, DSG1, EPKHE, EPKHIA, Pemphigus foliaceus antigen, PPKS1, SPPK1

Produktbeschreibung

Recognizes a protein of ~150kDa, identified as Desmoglein-1 (DSG1). Desmoglein-1 is a member of the desmosomal cadherin family.Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. Desmocollins and desmogleins are the main desmosomal transmembrane proteins. Desmogleins consist of Dsg1, Dsg2, Dsg3, and Dsg4 isoforms.Within the desmosome, the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 1 is synthesized exclusively in the suprabasal layers. Intact and functionally active desmoglein 1 is essential to epidermal integrity.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [MSVA-544M]
• Molekulargewicht: 150kDa (precursor), 160kDa (mature)
• Isotyp: IgG2a
• NCBI: 1828
• UniProt: Q02413
• Formulierung: Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide.

Bilder

Desmoglein-1 Mouse Monoclonal Antibody (MSVA-544M) tested on many normal and cancer tissues. The immunohistochemistry staining in these tissues aligns with the expression data in Human Protein Atlas.